Brentford beat Brighton 4-2 at the Gtech Community Stadium on Saturday in the pick of the 3pm kick offs.
Thomas Frank's side had gone into the game hoping to secure their first victory in over a month after failing to overcome the likes of Newcastle, Chelsea and Arsenal.
But the Bees picked up all three points on home soil, with Bryan Mbeumo the star of the show.
The Brentford star scored twice, with Yoane Wissa and Christian Norgaard also on target, while Danny Welbeck and Kaoru Mitoma's goals for Brighton ultimately counted for nothing.
Premier League results: Brentford and Manchester City won in the 3pm kick offs on Saturday
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To make matters worse for the visitors, Joao Pedro was sent off for violent conduct. A three-match ban for the forward now awaits.
Fans were hopeful that the match between Everton and Manchester City would produce something exciting.
After all, the Toffees have been tough to beat ever since David Moyes' return to the club - while City are continuing to push for Champions League football.
Fans at Goodison Park had to be patient, with the majority of the contest underwhelming.
But City were able to snatch all three points through late goals from Nico O'Reilly and Mateo Kovacic.
That's enough to move Pep Guardiola's team up to fourth ahead of Nottingham Forest's showdown with Tottenham on Monday night.
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Premier League results: Nico O'Reilly was on target as Man City beat Everton
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Over at West Ham, Graeme Potter desperately wanted to see his side beat Southampton.
The Hammers have struggled for consistency all season long and went into the game without a Premier League win since February 27.
West Ham weren't at their best against the Saints but looked set to get the job done when Jarrod Bowen struck in the 47th minute.
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However, Southampton snatched a late draw through Lesley Ugochukwu, with the Frenchman sparking wild celebrations in the away end.
Southampton are now up to 11 points, the same amount Derby amassed during their doomed 2007/08 campaign. One more point will ensure the Saints avoid joining the Rams in the history books.
Premier League results: Jarrod Bowen scored in West Ham's 1-1 draw with Southampton
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Bournemouth gave been flying this term, with the Cherries eager to secure European football.
They were held to a goalless draw by Crystal Palace at Selhurst Park, however, despite the Eagles being forced to play with 10 men following Chris Richards' red card.
