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The television personality was joined by her colleague, Janet Street-Porter
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Denise Welch was photographed belly laughing after Queen Camilla cracked a joke during a reception at Clarence House on Tuesday.
The television personality was joined by her Loose Women colleague Janet Street-Porter at the event marking SafeLives charity's 21st anniversary.
The Queen hosted around 100 guests, including survivors, frontline professionals and supporters of the charity, which aims to eradicate domestic abuse.
Camilla cut a birthday cake to celebrate the charity's milestone and was honoured with a "Starfish Award" in recognition of her support for survivors.
Denise Welch belly laughs after Queen Camilla cracks joke
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The Queen has been patron of SafeLives since 2020. She earned laughs from the crowd as she joked that they would be glad she was not giving a long speech.
In her brief address as "proud patron", she paid tribute to the charity, saying: "It's touched so many people and it's saved so many lives."
Among the guests were the parents of murdered schoolgirl Holly Newton, who met with the Queen to discuss their campaign.
Holly was 15 when she was killed in Hexham, Northumberland, by her stalker ex-boyfriend, Logan MacPhail, in January 2023.
Denise Welch, Janet Street-Porter and Queen Camilla posing at the event
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Micala and Lee Trussler are campaigning for the law to be changed so that people under 16 can be classed as victims of domestic abuse.
Speaking to reporters outside Clarence House after chatting with the Queen, Micala said: "She was really passionate about our campaign.
"She's supporting us in our campaign, and she's really looking to help young people as well."
It is understood Camilla was showing personal support for the family, not expressing backing for a political campaign.
Janet Street-Porter also burst out laughing at Queen Camilla's joke
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Micala added that the Queen expressed sorrow for their loss, saying: "She's very interested in our campaign and she's sorry for our loss and that we shouldn't have to be here doing this."
Her husband, Lee, welcomed the royal attention to their cause: "We feel like it's good because it's getting heard in the highest place in the country, essentially."
"So we're hoping that other people are going to take notice that the Queen's paying attention and supporting."
The Queen also spoke with Diana Parkes, whose daughter Joanna Simpson was killed by her estranged husband in 2010.
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The Queen has been patron of SafeLives since 2020
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Parkes said they discussed how to eliminate domestic abuse and concerns about youth violence.
The pair also spoke about social media, with Camilla overheard calling it "terrifying". Parkes told reporters: "Social media plays a huge part in all this, it's so sad. The internet has been wonderful, but my god, it's done a lot of damage as well."
In her speech, Camilla reflected on how discussions about domestic abuse have evolved: "I would not be standing here if it was 10 years ago, and none of these people would have been standing here because we wouldn't have been talking about it - it was a taboo subject.
"But now here we are, 10 years later, we've got survivors telling their stories. So it's just to say we've come a really long way, so we must go on doing the same thing."