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The Duke of Sussex previously travelled to the UK and Ukraine without the Duchess
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Meghan Markle is set to leave California without Prince Harry in just days.
The Duchess of Sussex is due in New York City on April 23 for an important summit alongside Ryan Reynolds and Demi Moore.
Meghan, 43, will join "the world's most influential people" at the fifth-annual TIME100 summit in New York City later this month.
Prince Harry, 40, has not been listed as a keynote speaker, and it has not been confirmed if the Duke of Sussex will accompany his wife to NYC.
Meghan Markle to leave California without Prince Harry in just days
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He previously travelled to the UK and Ukraine without the Duchess, before returning to their home in Montecito, California.
The TIME100 Summit website describes the event as featuring "leaders from the global TIME community to spotlight solutions and encourage action toward a better world".
Alongside Meghan, who is listed as "Duchess of Sussex and founder of As ever", other notable speakers include actor Ryan Reynolds.
The summit will bring together influential figures across various industries for the day-long event on April 23.
It is not currently known if Meghan and Harry will attend the TIME100 Gala, which will take place the following day on April 24.
The gala will be hosted by Snoop Dogg, who is also one of this year's cover stars.
TIME Studios and ABC will air footage from inside the gala, titled "TIME100: The World's Most Influential People," on Sunday, May 4.
The prestigious magazine has also revealed its annual list of the 100 most influential people in the world for 2025, with five different personalities gracing the worldwide covers.
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Serena Williams, former tennis player and entrepreneur, is among those featured on the covers, alongside actor and producer Demi Moore, artist Snoop Dogg, singer-songwriter Ed Sheeran, and Google DeepMind CEO Demis Hassabis.
Meghan's invitation to speak positions her among what TIME describes as the "world's most influential people" despite her absence from this year's cover selections.
The Duchess of Sussex along with her husband, Prince Harry, were previously included on the front cover of Time Magazine in 2021.