A Tui flight from Tunisia to Manchester was forced to make an emergency landing in Nice, France overnight, marking the airline's second emergency landing this week.
The diversion due to a medical emergency comes just days after another Tui aircraft had to make an emergency landing at Gatwick Airport on Wednesday after striking two swans.
Both incidents have caused significant disruption to the airline's scheduled services.
Flight TOM529 was scheduled to depart Enfidha-Hamamet Airport at 8.15pm local time on Friday, with an expected arrival in Manchester at 10.40pm.
A TUI flight from Tunisia to Manchester was forced to make an emergency landing in Nice
GETTYThe flight, already delayed, didn't take off until around 11pm before being diverted to Nice Côte d'Azur Airport.
Flight tracking data showed the aircraft eventually departed Nice just after 12.30am on Saturday morning, finally touching down in Manchester at approximately 1.15am.
A passenger was taken away by ambulance after landing in Nice.
Passenger Phil Rawnsley, speaking to the Manchester Evening News, described how the medical emergency unfolded during the flight.
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"About an hour into the flight, just as the drinks trolley was coming round, a call went out 'is there a doctor or nurse on the plane?'," he said.
"Paramedics and police boarded the plane in Nice. Once they had taken the passenger off the plane we had to refuel and then continue our journey."
The Boeing 737, operating as TUI service BY432 to Cape Verde, struck two swans shortly after takeoff from London Gatwick Airport on Wednesday.
Pictures of the aircraft showed bloodstains on the co-pilot's windscreen and impact damage to the Boeing's nose cone.
The flight touched down in Manchester at approximately 1:15am
GETTYThe pilots were forced to enter a holding pattern over Sussex to burn off excess fuel before making a safe landing.
No injuries were reported in the incident.
A Tui spokesman confirmed that the 150 passengers affected by Wednesday's bird strike incident were able to continue their journey to Cape Verde on a replacement aircraft about three hours later.
The spokesman also denied earlier reports that a "mayday" broadcast had been made during the incident.
