The skincare industry continues to evolve with innovative treatments that offer complementary benefits.
Polynucleotides and hyaluronic acid are two advancements that work synergistically to improve skin health.
Hyaluronic acid is renowned for its hydrating properties, but polynucleotides stimulate the body's production of hyaluronic acid and regenerate fibroblast activity, explained co-founder of science-driven skin care brand Miskonceptions, Silvia Bonino.
This combination addresses multiple skin concerns simultaneously; while hyaluronic acid provides immediate moisture, polynucleotides work at a deeper level to promote long-term skin renewal.
Polynucleotides are essentially DNA fragments that actively regenerate the skin while stimulating collagen and elastin production. This process enhances the skin's structural integrity at a cellular level.
Polynucleotides actively reduce inflammation
GETTYSilvia told GB News: "Polynucleotides regenerate fibroblasts, boost collagen and elastin production, and improve skin structure, making them highly effective for deep wrinkles, sagging, and atrophic scars.
"Unlike hyaluronic acid, which mainly hydrates, polynucleotides actively reduce inflammation, making them ideal for eczema-prone, rosacea-affected, or sensitive skin.
Research published in the Journal of Cosmetic Dermatology last year that when used as an injection, the treatment shows promise in improving skin texture and reducing wrinkles, with several studies yielding significant results.
Polynucleotides offer more noticeable results than hyaluronic acid alone for several specific skin concerns.
Hyaluronic acid primarily aids in hydration and reducing fine lines and its regenerative effects are more limited compared to polynucleotides.
Polynucleotides work to stimulate fibroblast activity, explained Silvia, who explained this is essential for improved skin renewal and regeneration.
Unlike hyaluronic acid, polynucleotides actively reduce inflammation, benefiting those with eczema-prone, rosacea-affected or sensitive skin.
They accelerate healing after laser treatments or chemical peels by promoting new blood vessel formation.
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Hyaluronic acid aids in hydration and reducing fine lines
GETTYPolynucleotides also help rebalance melanogenesis, reducing pigmentation issues and melasma.
For scarring, they stimulate cellular repair, proving effective for acne scars and stretch marks.
"Hyaluronic acid alone is excellent for hydration and fine lines, but polynucleotides offer deeper, long-lasting regenerative benefits, especially for compromised or ageing skin," explained Silvia.
Though the ingredient is commonly injected into the skin it can also be applied topically, offering a more natural approach.
Some scientists suggest combining the topical treatment with effective delivery systems like microneedling may offer the most impressive regenerative effects.
