Harry Kane suffered another difficult night at Bayern Munich as he saw his side lose 1-0 in the first leg of the Champions League last-16 tie against Lazio on Wednesday.
Bayern were beaten 3-0 by their nearest Bundesliga rivals Bayer Leverkusen last Saturday but there was more misery for Thomas Tuchel in Rome.
Ciro Immobile scored the only goal of the game for the hosts from the penalty spot after Dayot Upamecano was sent off for a tackle on Gustav Isaksen.
Kane missed a big chance in the first half but was largely unable to have a positive impact in his first knockout game for Bayern.
Harry Kane and Bayern Munich were beaten 1-0 by Lazio in the Champions League
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The England captain moved to Germany from Tottenham last summer in the quest of winning trophies for the first time in his career.
However, Bayern are in danger of missing out on the Bundesliga title for the first time in 11 years.
Leverkusen are now five points clear at the top of the table following last weekend's impressive win at home.
Bayern will have hoped to have bounced back in a favourable tie against Lazio, who sit seventh in Italy's Serie A.
Kane was signed to make the difference in the big matches but was unable to do so in the first leg.
And fans gave a savage reaction to Bayern's defeat on social media, aiming criticism at the 30-year-old.
One fan wrote on X: "Kane is so cursed man.."
While another put: "The Harry Kane effect. The bottler gene is strong with this one."
One supporter blamed Tuchel for Kane's ineffective performance, writing: "This is the problem with Kane, he’s too good at everything so managers wanna put him on the halfway line and tell him to be a quarterback when it reality he should be in the box scoring goals."
Kane's 'curse' of not winning trophies so far in his career was a familiar theme on X.
Another user wrote: "The Harry Kane curse is real look at Bayern Munich #LAZFCB."
While another wrote: "Also you can take Harry Kane out of Spurs but you can't take Spursiness out of Kane and he has brought that to Bayern this season."
Some fans refused to blame Kane for Bayern's recent results.
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Harry Kane was unable to make the difference for Bayern Munich against Lazio
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One wrote: "It’s not Harry Kane’s fault by the way that Bayern Munich are not doing well."
And another posted: "Damn, Harry Kane can't catch a break lol."
Bayern will now look to overturn the first-leg deficit when they welcome Lazio to the Allianz Arena on March 5.
Ahead of Wednesday's match, former Manchester United defender Rio Ferdinand admitted Kane was under big pressure to deliver silverware.
Harry Kane struggled to make an impact as Bayern Munich lost to Lazio
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Ferdinand said on TNT Sports: "I'd love to be in his head and just listen to the voices at the moment because I think the pressure on him is huge. Especially now they're five points behind in the league.
"The only thing that anyone has ever thrown at him is that he hasn't got trophies and there's a chance he could be at Bayern and not win a trophy this year.
"It would be the first time in 11 years they haven't won the league. So the pressure in his head right now must be huge."